Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Genetic overlap between diagnostic subtypes of ischemic stroke.
BACKGROUND AND PURPOSE Despite moderate heritability, the phenotypic heterogeneity of ischemic stroke has hampered gene discovery, motivating analyses of diagnostic subtypes with reduced sample sizes. We assessed evidence for a shared genetic basis among the 3 major subtypes: large artery atherosclerosis (LAA), cardioembolism, and small vessel disease (SVD), to inform potential cross-subtype an...
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Background and Purpose—Twin and family history studies support a role for genetic factors in stroke risk. Because the etiology of ischemic stroke is heterogeneous, genetic factors may vary by etiologic subtype. We determined the familial aggregation of stroke risk in different stroke phenotypes and used the results to model estimated sample size requirements for case-control studies. Methods—On...
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BACKGROUND AND PURPOSE Lacunar stroke is associated with an intrinsic cerebral small vessel disorder of unknown etiology, although possible causes include increased blood-brain barrier permeability. Retinal arterioles are similar to cerebral small vessels and retinopathy occurs secondary to increased blood-retinal barrier permeability. We hypothesized that there would be higher rates of retinop...
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Background: Epidemiological research has shown that increased total homocysteine (tHcy) levels are associated with an increased risk of thromboembolic disease; however, controversy still exists over which subtype of stroke is allied to hyperhomocysteinemia. This study aimed to investigate whether elevated tHcy is an independent risk factor for ischemic stroke and to compare tHcy levels in patie...
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Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world. Epidemiological data provides evidence for a genetic component to the disease, but its epigenetic involvement is still largely unknown. Epigenetic mechanisms, such as DNA methylation, change over time and may be associated with aging processes an...
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ژورنال
عنوان ژورنال: Stroke
سال: 2015
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.114.007930